Title:
【発明の名称】エンドサイトーシスにより高等真核細胞に吸収されうる新規核酸含有複合体
Document Type and Number:
Japanese Patent JPH06504993
Kind Code:
A
Abstract:
Complexes between internalisation factor-binding factor conjugates and nucleic acid which can be absorbed into higher eucaryotic cells via endocytosis contain, in non-covalently bonded form, one or more substances with an affinity for nucleic acid with the ability to increase the efficiency of the absorption of the complexes into the cell. The non-covalently bonded substance with an affinity for nucleic acid may be the same as the binding factor, and preferably a polycationic substance. The preferred internalisation factor is transferrin. Process for producing the complexes and process for introducing nucleic acid into higher eucaryotic cells. Pharmaceutical preparations containing complexes with a therapeutically active nucleic acid.
Inventors:
Billund Steal Max L
Kotten Matthew
Wagner Ernst
Kotten Matthew
Wagner Ernst
Application Number:
JP50350892A
Publication Date:
June 09, 1994
Filing Date:
February 01, 1992
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
Genentech Incorporated
Genentech Incorporated
International Classes:
A61K47/48; (IPC1-7): A61K47/48
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)