Title:
【発明の名称】内皮細胞の増殖に対する新規抑制因子
Document Type and Number:
Japanese Patent JPH06505243
Kind Code:
A
Abstract:
PCT No. PCT/EP92/00419 Sec. 371 Date Nov. 10, 1993 Sec. 102(e) Date Nov. 10, 1993 PCT Filed Feb. 27, 1992 PCT Pub. No. WO92/15606 PCT Pub. Date Sep. 17, 1992.In order to isolate an inhibitor of the proliferation of endothelial cells from the tissue of vertebrates the tissue selected as the starting material e.g. embryonic tissue or adult brain tissue from birds or mammals, is centrifuged, homogenized and subsequently the tissue extract is applied to a cation exchanger and the substances which bind to the cation exchanger are subjected to a fractionation, the active fractions are separated by gel filtration chromatography and they are purified by reverse phase HPLC. The new inhibitor obtained in this way is suitable for treating disease states in which an inhibition of capillary growth is necessary such as for the treatment of tumors, rheumatoid arthritis, diabetic retinopathy and retrolental fibroplasia and for treating wounds in order to regulate the regeneration of blood vessels.
Inventors:
Riesau, Werner
Drexler, hannes
Drexler, hannes
Application Number:
JP50494692A
Publication Date:
June 16, 1994
Filing Date:
February 27, 1992
Export Citation:
Assignee:
Max-Plank-Gezelle Shaft Tool Felderung del Wissenschaffen A Fau
International Classes:
A61K35/30; A61K35/48; A61K38/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07K1/16; C07K1/18; C07K1/20; C07K14/435; C07K14/47; (IPC1-7): C07K3/22; A61K35/30; A61K35/48; A61K37/02; C07K3/20; C07K15/06
Attorney, Agent or Firm:
Toshio Yano (2 outside)