Title:
【発明の名称】改変ヌクレオシド間結合
Document Type and Number:
Japanese Patent JPH06505704
Kind Code:
A
Abstract:
Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used as diagnostic reagents to detect the presence or absence of the target DNA or RNA sequences to which they bind.
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Inventors:
Mateucci, mark
Jones, Robert Jay.
John Manger
Jones, Robert Jay.
John Manger
Application Number:
JP51755691A
Publication Date:
June 30, 1994
Filing Date:
September 20, 1991
Export Citation:
Assignee:
Gilead Sciences, Inc.
International Classes:
A61K31/70; A61K31/7088; A61P43/00; C07D405/04; C07H19/06; C07H19/10; C07H21/00; C07H21/04; C12N15/00; (IPC1-7): C07H21/04; A61K31/70; C07H21/00
Attorney, Agent or Firm:
Shusaku Yamamoto