Title:
【発明の名称】コラゲナーゼ阻害剤としてのアザラクタムヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JPH06505989
Kind Code:
A
Abstract:
Hydroxamic acid derivatives for use as medicaments, of formula (1), or a salt, solvate or hydrate thereof, in which R1 is hydrogen, C1-6alkyl, or -(CH2)n-A-R4 where n is from 0 to 6, A is a bond or an oxygen or sulphur heteroatom and R4 is an optionally substituted aryl or optionally substituted heteroaryl group; R2 is C3-6alkyl; and R3 is -(CH2)p-X-(CH2)q- where p is an integer from 1 to 9, q is an integer from 2 to 10, and the moiety -(CH2)p- is adjacent to the carbon atom marked with an asterisk in formula (1), and X is -NR5- where R5 is selected from hydrogen, C1-6 alkyl, C2-6 alkanoyl, C1-6 alkoxycarbonyl and aryl, aralkyl or aralkyloxycarbonyl in each of which the aryl moiety is optionally substituted.
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Inventors:
Markwell, Roger Edward
Ward, robert william
Rahman, Shah Zad Sharuk
Ward, robert william
Rahman, Shah Zad Sharuk
Application Number:
JP50717892A
Publication Date:
July 07, 1994
Filing Date:
April 06, 1992
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/395; A61P3/00; C07D245/02; (IPC1-7): C07D245/02; A61K31/395
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)