Title:
【発明の名称】3α-ヒドロキシ、3β-置換-プレグナンの製造法
Document Type and Number:
Japanese Patent JPH06507427
Kind Code:
A
Abstract:
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3 alpha -hydroxy,3 beta -substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into a 3(R)-pregnan-3-spiro-2'oxirane-20-one intermediate. This intermediate can then be converted regioselectively by a second set of reactions to the 3 alpha -hydroxy,3 beta -substituted-20-one form, which can be further modified at the 20-keto position. Through this method, each ketone group is independently treated. By modifying the ketones one at a time, one can obtain the desired stereo-specificity at each site.
Inventors:
Tahia, Sued Hathan
Bolger, Michael Bruce
Buswell, Richard
Gabriel, Richard
Stearns, Jay
Bolger, Michael Bruce
Buswell, Richard
Gabriel, Richard
Stearns, Jay
Application Number:
JP51572793A
Publication Date:
August 25, 1994
Filing Date:
February 22, 1993
Export Citation:
Assignee:
Cosensys, Inc.
International Classes:
A61K31/565; A61K31/57; A61K31/58; C07J5/00; C07J1/00; C07J3/00; C07J7/00; C07J9/00; C07J13/00; C07J17/00; C07J21/00; C07J41/00; C07J43/00; C07J51/00; C07J71/00; C07J75/00; (IPC1-7): C07J75/00; C07J5/00; C07J21/00
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)