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Title:
【発明の名称】ホスフィットボラン化合物とその製法ならびに用途
Document Type and Number:
Japanese Patent JPH06507896
Kind Code:
A
Abstract:
Phosphite-borane compounds of the formula wherein: each R1 is independently selected from: H; C1-C10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R4)4N+, in which the substituents R4 of the ammonium nitrogen atom are H or C1-C10 alkyl; R2 is H or C1-C10 alkyl; and R3 is CNCH2CH3+BF4-, COOH, carboxyl salts, COOR5, or CONHR5, wherein R5 is C1-C10 alkyl, alkylaryl, aralkyl, or aryl; with the proviso that if at least one of the R1 substituents is H, nucleoside, monovalent metal ion, or quaternary ammonium ion, then R3 may also be CN. The phosphorous-boron adducts of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity. Also disclosed are various synthetic methods for making such phosphorous-boron compounds, and for formulating same in unit dosage forms as well as other pharmaceutically and pharmacologically acceptable formulations.

Inventors:
Spiel Vogel Bernard F
Soup. Anup
Hall. Iris. Etch
Application Number:
JP50009592A
Publication Date:
September 08, 1994
Filing Date:
May 08, 1992
Export Citation:
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Assignee:
Boron Biologicals, Inc.
International Classes:
A61K31/69; A61K31/70; A61K31/7135; A61P3/06; A61P29/00; A61P35/00; C07F9/06; C07F9/141; C07F19/00; C07H23/00; (IPC1-7): C07F19/00; A61K31/69; A61K31/70; C07F9/06; C07H23/00
Attorney, Agent or Firm:
Yoshihisa Oshida