Title:
【発明の名称】新規かつ改良されたエーテル性置換保護モノサッカライドの溶媒不在合成方法およびそれらの選択的加水分解
Document Type and Number:
Japanese Patent JPH06508107
Kind Code:
A
Abstract:
A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; 2) heating the mixture to a temperature sufficient to allow the mixture to react; 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups. e
Inventors:
Ellora, Sadarshan Kay.
Application Number:
JP50662392A
Publication Date:
September 14, 1994
Filing Date:
February 07, 1992
Export Citation:
Assignee:
Boston Life Sciences, Inc.
International Classes:
C07H9/04; C07H15/04; C07H1/00; (IPC1-7): C07H15/04; C07H9/04; C07H1/00
Attorney, Agent or Firm:
Akira Asamura (3 outside)