Title:
【発明の名称】慢性疲労症候群の治療用組成物
Document Type and Number:
Japanese Patent JPH06510749
Kind Code:
A
Abstract:
The present invention relates to a method of treating chronic fatigue syndrome not associated with an HIV infection. In the method of the present invention patients are administered a pharmaceutically acceptable carrier together with (1) a neuropsychiatrically effective amount of a linear peptide of formula (I): Ra-Ser-Thr-Thr-Thr-Asn-Tyr-R6(I) wherein Ra is Ala, D-Ala or Cys-Ala-, and R6 is Thr, Thr-amide, Thr-Cys or Thr-Cys-amide, or a derivative of the peptide or a physiologically acceptable salt thereof; or (2) a neuropsychiatrically effective amount of a linear peptide of formula (II): R1-R2-R3-R4-R5(II) wherein R1 is X-Y or Y when Y is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu-, and X is Cys; R2 is Thr-, Ser- or Asp; R3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp; R4 is Tyr; and R5 is Z-X or Z wherein Z is any amino acid and X is Cys, or a derivative of the peptide or a physiologically acceptable salt thereof; or (e) a neuropsychiatrically effective amount of a linear peptide of formula (III): Rx-R2-R3-R4-Ry(III) wherein Rx is Ala-R1, D-Ala-R1 or X-Ala-R1 wherein X, R1, R2, R3, R4 are as defined above, and Ry is Thr-, Thr-amide or Thr-Cys, or a derivative of the peptide or a physiologically acceptable salt thereof.
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Inventors:
Bridge, thomas peter
Goodwin, Frederick Kay
Goodwin, Frederick Kay
Application Number:
JP51195692A
Publication Date:
December 01, 1994
Filing Date:
May 08, 1992
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
A61K38/00; A61K38/16; A61K38/17; A61K47/40; A61P25/00; C07K7/08; C07K14/16; C07K14/73; (IPC1-7): A61K37/02
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)