【発明の名称】インドール類

Japanese Patent JPH06511483

A

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X is O, NH, N(C1-C4 alkyl), C1-C4 alkylene, C2-C4 alkenylene or C2-C4 alkynylene, said alkylene, alkenylene and alkynylene groups being optionally substituted by C1-C4 alkyl or aryl; Y is C1-C6 alkylene optionally substituted by C1-C6 alkyl; R is H, OH, halo, C1-C4 alkyl or C1-C4 alkoxy; R<1>, R<2>, R<3> and R<4> are each independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, OH, halo and CF3; one of R<6>, R<7> and R<8> is C1-C15 alkyl or a group of the formula -Z(C1-C15 alkyl), -Z(aryl) or -Z(C3-C7 cycloalkyl), said alkyl group being optionally interrupted by O, S(O)q, NH or N(C1-C6 alkyl), and said alkyl group and the alkyl group of said -Z(C1-C15 alkyl) group being optionally substituted by C1-C10 alkoxy, aryl, C3-C7 cycloalkyl or a group of the formula -Z(aryl), and the remainder of R<6>, R<7> and R<8> and R<5> and R<9> are each independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo and halo(C1-C4 alkyl); R<10> is COOH, COOR<11> or CONR<12>R<13>; R<11> is a biolabile ester-forming group; R<12> and R<13> are each independently selected from H and C1-C4 alkyl; Z is O, S(O)q, NH or N(C1-C6 alkyl); q is 0, 1 or 2; and ''aryl'' used in the definitions of X, R<6>, R<7> and R<8>, means phenyl optionally substituted by C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, OH, halo, CF3, halo(C1-C6 alkyl), nitro, amino, C2-C6 alkanamido, C2-C6 alkanoyl or phenyl: together with pharmaceutical compositions containing, processes for the preparation of and uses of, such compounds.

Bragg, The Julian
Cooper, Kelvin
Spago, Peter Lionel

JP50259293A

December 22, 1994

July 20, 1992

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Father Incorporated

A61K31/403; A61K31/404; A61K31/405; A61P3/06; A61P13/02; A61P15/00; A61P17/00; A61P43/00; C07D209/12; C07D209/42; (IPC1-7): C07D209/42

Yoshio Kawaguchi (2 outside)

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