【発明の名称】キノン誘導体

Japanese Patent JPH0678268

B2

Quinone derivatives of the general formula:(wherein R¹ and R² are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R¹ and R² combine with each other to represent -CH =CH-CH = CH-; R³ is a hydrogen atom or a methyl group; R⁴ is an aliphatic, aromatic or heterocyclic group which may be substituted; R⁵ is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by -C≡C-,orn is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, posses metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity) or production inhibitory activity of 5-lipoxygenase metabolites in mammals, and are of use as drugs, such as antiasthmatic, antiallergic agent and cerebral-circulatory metabolism ameliorating agent.

TERAO SHINJI
MAKI YOSHITAKA

JP20735690A

October 05, 1994

August 03, 1990

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TAKEDA CHEMICAL INDUSTRIES LTD

A61K31/047; A61K31/122; A61K31/16; A61K31/19; A61K31/215; A61K31/38; A61K31/381; A61P3/06; A61P9/00; A61P9/10; A61P11/00; A61P11/14; A61P17/00; A61P29/00; A61K31/12; A61P37/08; A61P43/00; C07C39/11; C07C45/29; C07C46/00; C07C46/02; C07C46/06; C07C47/277; C07C50/00; C07C50/04; C07C50/06; C07C50/08; C07C50/14; C07C50/28; C07C50/30; C07C50/32; C07C59/86; C07C59/90; C07C66/00; C07C69/145; C07C69/734; C07C69/92; C07C259/10; C07C271/12; C07D333/22; C07D333/24; C07D333/38; C07D521/00; (IPC1-7): C07C50/30; C07C50/32; C07C59/86; C07C59/90; C07C66/00; C07C69/734; C07C69/92; C07C259/10; C07D333/38

Hiroshi Iwata (4 outside)

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