Title:
【発明の名称】α-(アルキルフェニル)-4-(ヒドロキシジフェニルメチル)-1-ピペリジンブタノールの製造方法
Document Type and Number:
Japanese Patent JPH0681743
Kind Code:
B2
Abstract:
A process for preparing alpha-(alkylphenyl)-4-(hydroxy diphenylmethyl)-1-piperidine butanol of formula (I) in which R is a C1-C5 alkyl, consisting of reacting an isonipecotate of formula (II): in which R min is a C1-C5 alkyl or an arylalkyl such as benzyl, with 1-(alkylphenyl)-4-chlorobutanol (III) or with 1-(alkylphenyl)-3-chloropropylketone (VI), in both of which the alkyl group is C1-C5, to obtain the compound (IV) either directly or after reduction of the ketone group: and reacting (IV) with phenylmagnesium halide (V) to obtain (I).
Inventors:
EJIDEIO MORINAARI
Application Number:
JP12724988A
Publication Date:
October 19, 1994
Filing Date:
May 26, 1988
Export Citation:
Assignee:
EREJIIRE IND CHIMIKA SPA
International Classes:
B01J27/232; C07D211/22; C07D211/62; (IPC1-7): C07D211/22
Other References:
【文献】
【文献】ChemicalABSTHACTS,107[3〕(1984)抄録番号23250y
【文献】ChemicalABSTHACTS,107[3〕(1984)抄録番号23250y
Attorney, Agent or Firm:
Yamashita
Next Patent: ２，４−ジオキシキノリン誘導体の製造方法