Title:
【発明の名称】グアニジン含有HIVプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JPH07501056
Kind Code:
A
Abstract:
Compounds of formula (I) wherein R<1> and A are amino terminal groups: Z is O or N-R<2>; M is a dipeptide isostere; and D1 and D2 are optionally absent or amino acids; and pharmaceutically acceptable salts thereof, are potent inhibitors of the HIV-1 protease and are useful in the treatment of viral diseases such as Acquired Immune Deficiency Syndrome (AIDS).
Inventors:
Gleason, John Gerald
Lamb, Robert Thomas
Lamb, Robert Thomas
Application Number:
JP50865993A
Publication Date:
February 02, 1995
Filing Date:
October 30, 1992
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/155; A61K31/17; A61K31/41; A61K31/415; A61K31/42; A61K31/421; A61K31/4245; A61K31/425; A61K31/426; A61K31/433; A61P31/12; A61P31/18; C07C275/50; C07C279/22; C07C311/15; C07C317/14; C07C327/04; C07C327/38; C07C329/04; C07C329/14; C07C333/08; C07D233/64; C07D249/02; C07D249/08; C07D263/32; C07D271/10; C07D277/22; C07D285/12; C07F9/30; C07F9/32; C07K1/10; C07K1/113; C07K5/02; C07K5/03; C07K14/81; (IPC1-7): C07C275/50; A61K31/155; A61K31/17; A61K31/41; A61K31/415; A61K31/42; A61K31/425; C07C279/22; C07C311/15; C07C317/14; C07C327/04; C07C327/38; C07C329/04; C07C329/14; C07C333/08; C07D233/64; C07D249/08; C07D263/32; C07D271/10; C07D277/22; C07D285/12; C07F9/30; C07F9/32; C07K1/10; C07K5/03
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)