【発明の名称】抗菌コートした医療用埋没物 - Board of Regents, The University of Texas System

Title:

【発明の名称】抗菌コートした医療用埋没物

Document Type and Number:

Japanese Patent JPH07501470

Kind Code:

A

Abstract:

An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.

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Inventors:

Rudd, Issam Eye
Darawyche, Laby Oh

Application Number:

JP51592493A

Publication Date:

February 16, 1995

Filing Date:

March 04, 1993

Export Citation:

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Assignee:

Board of Regents, The University of Texas System

International Classes:

A01N1/02; A61L29/00; A61K31/65; A61L27/00; A61L27/54; A61L29/16; A61M25/00; (IPC1-7): A61L29/00

Attorney, Agent or Firm:

Kyozo Yuasa (6 people outside)

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