Document Type and Number:
Japanese Patent JPH07502404
Kind Code:
A
Abstract:
Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1 alpha which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.
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Application Number:
JP51127592A
Publication Date:
March 16, 1995
Filing Date:
December 23, 1992
Export Citation:
International Classes:
C12N15/09; C07K14/52; C12N1/19; C12N1/21; C12N15/19; C12N15/67; C12N15/81; C12P21/02; A61K38/00; C12R1/84; (IPC1-7): C12P21/02; C12N1/19; C12N15/09