Title:
【発明の名称】3‐アリールインドールおよび1‐アリールインダゾール誘導体の精神病の治療のための使用
Document Type and Number:
Japanese Patent JPH07503240
Kind Code:
A
Abstract:
3-Arylindole or 3-arylindazole derivatives having general formula (I) wherein Ar is optionally substituted phenyl or a hetero aromatic group; R<1>-R<4> are hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, alkylsulfonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio; X is N, CR<6>, R<6> being H, halogen, trifluoromethyl or alkyl, or CH2; Y is N, CH or C; R<5> is H, alkyl, alkenyl, cycloalkyl, or cycloalkylalkyl, or R<5> is a substituent of formula (1a) or (1b), wherein n is 2 - 6; W is O or S; U is N or CH; Z is -(CH2)m-, -CH=CH-, phenylene, -COCH2-, or -CSCH2-; V is O, S, CH2 or NR<7> wherein R<7> is H, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl; U<1> is O, S, CH2 or NR<8>; and V<1> is NR<9>R<10>, OR<11>, SR<12> or CR<13>R<14>R<15>, where each of R<8>-R<15> are as defined for R<7>; inhibit the firing of spontaneously active dopamine neurones in the ventral tegmental area of the brain and are thus useful for the treatment of psychoses in humans.
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Inventors:
Andersen Kim
Skullsfeld Thorben
Skullsfeld Thorben
Application Number:
JP51286593A
Publication Date:
April 06, 1995
Filing Date:
January 22, 1993
Export Citation:
Assignee:
Her Lundbeck Actieselskab
International Classes:
A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/415; A61K31/44; A61K31/4427; A61K31/443; A61K31/445; A61P25/18; C07D231/56; A61P25/20; C07D209/10; C07D401/04; C07D401/14; C07D405/04; (IPC1-7): A61K31/40; A61K31/41; A61K31/415; A61K31/44; A61K31/445
Attorney, Agent or Firm:
Mitsuyoshi Esaki (3 outside)