Title:
【発明の名称】酢酸誘導体
Document Type and Number:
Japanese Patent JPH07503459
Kind Code:
A
Abstract:
The invention relates to acetic acid derivatives of formula (I) and pharmaceutically acceptable derivatives thereof and salts and solvates thereof, where: X<1> and Y<1>, which may be the same or different, represent CH or N; X<2> represents CH or, when X<1> represents CH, may also represent N; Y<2> represents N or, when Y<1> represents N, may also represent CH; Z represents N or N<+>R<5>; R<1> represents a hydrogen atom or a hydroxyl, C1-4alkyl or 2,2,2-trifluoroethyl group; R<2> represents a hydrogen atom or, when both X<1> and X<2> represent CH, may also represent a fluorine, chlorine or bromine atom or a C1-4alkyl group; R<3> represents a hydrogen atom or, when both Y<1> and Y<2> represent N, may also represent a C1-4alkyl or hydroxymethyl group; R<4> represents a hydrogen atom or, when Z represents N, R<4> may also represent a C1-4alkyl group; R<5> represents a C1-4alkyl or phenylC1-4alkyl group; R<6> represents a naphthyl group; a thiophenyl group; an unsubstituted phenyl group; a phenyl group substituted by C1-4alkyl, C1-4alkoxy, phenylC1-3alkoxy, OH, halogen, where halogen is fluorine, chlorine, bromine or iodine, CF3, unsubstituted phenyl, phenyl substituted by OH, pyridinyl, NR<7>R<8>, NHSO2R<7>, CONR<7>R<8> or CO2R<7>; a C1-4alkyl group substituted by one or more naphthyl, phenyl, OH or CO2R<7>; a C2-4alkenyl group substituted by one or more naphthyl, phenyl, OH or CO2R<7>; or a saturated or unsaturated C5-7cycloalkyl group; and R<7> and R<8>, which may be the same or different represent H or C1-4alkyl or, together with the nitrogen atom to which they are attached, form a saturated 5 to 7 membered ring. The compounds inhibit fibrinogen dependent blood platelet aggregation.
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Inventors:
Barry, Porter
Eldred, Colin David
Brian David, Judkins
Kelly, Henry Anderson
Wheatcroft, James Russell
Eldred, Colin David
Brian David, Judkins
Kelly, Henry Anderson
Wheatcroft, James Russell
Application Number:
JP51215893A
Publication Date:
April 13, 1995
Filing Date:
January 15, 1993
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
A61K31/4427; A61K31/4433; A61K31/445; A61K31/4468; A61K31/495; A61P7/02; C07D211/26; A61P9/00; A61P9/08; A61P9/10; A61P13/02; A61P15/00; A61P27/02; A61P35/00; A61P43/00; C07D211/58; C07D401/12; C07D409/04; C07D409/06; (IPC1-7): C07D211/26; A61K31/445; A61K31/495; C07D211/58; C07D401/12; C07D409/04
Attorney, Agent or Firm:
Kazuo Sato (2 outside)