Title:
【発明の名称】細胞を脳に移植する方法及びその治療使用
Document Type and Number:
Japanese Patent JPH07503467
Kind Code:
A
Abstract:
A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 mu m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.
Inventors:
Churksey Bruce Dee
Application Number:
JP51330593A
Publication Date:
April 13, 1995
Filing Date:
January 21, 1993
Export Citation:
Assignee:
New York University
International Classes:
A61K9/00; A61K9/16; A61K35/12; A61K35/22; A61K35/30; A61K35/33; A61K47/48; A61K48/00; A61L27/38; A61P25/00; C12N5/071; (IPC1-7): A61K35/12; A61K48/00
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)