Document Type and Number:
Japanese Patent JPH07504423
Kind Code:
A
Abstract:
The present invention provides conjugate compounds comprising at least one heat shock protein or portion thereof including at least one immunostimulatory domain and at least one capsular oligosaccharide or polysaccharide of a pathogenic bacteria. The compound comprises oligosaccharides of the Meningococci C (MenC) group and a heat shock protein selected from M. bovis BCG GroE1-type 65 kDa hsp (hspR65), recombinant M. tuberculosis DnaK-type 70 kDa hsp (hspR70) and a heat shock protein from H. pylori. The invention also provides processes for producing conjugate compounds, pharmaceutical compositions comprising conjugate compounds, therapeutic compositions comprising conjugate compounds, and methods of inducing an immune response.
Application Number:
JP51533393A
Publication Date:
May 18, 1995
Filing Date:
March 08, 1993
Export Citation:
International Classes:
C12N15/09; A61K39/00; A61K39/095; A61K39/385; A61K47/48; A61P31/04; A61P37/04; C07K14/195; C07K14/205; C07K14/35; C07K14/41; C07K19/00; C08B37/00; C12P21/02; A61K38/00; (IPC1-7): A61K47/48; A61K39/385; C07K14/195