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Document Type and Number:
Japanese Patent JPH07504900
Kind Code:
A
Abstract:
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.

Application Number:
JP51569893A
Publication Date:
June 01, 1995
Filing Date:
February 18, 1993
Export Citation:
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International Classes:
A61K31/70; A61K31/7088; A61K31/74; C07H21/04; A61P31/12; C07H21/00; C07J43/00; C07J51/00; C08B37/00; (IPC1-7): C07H21/04; A61K31/70; C08B37/00



 
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