Title:
【発明の名称】ステロイダルペルアシル配糖体の合成法
Document Type and Number:
Japanese Patent JPH07504920
Kind Code:
A
Abstract:
PCT No. PCT/US93/02812 Sec. 371 Date Dec. 20, 1994 Sec. 102(e) Date Dec. 20, 1994 PCT Filed Apr. 2, 1993 PCT Pub. No. WO94/00479 PCT Pub. Date Jan. 6, 1994Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting alpha -cellobiosyl bromide heptaalkanoate and beta -tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl beta -O-cellobioside heptaalkanoate. The analogous preparations of hecogenin beta -O-cellobioside heptaalkanoate 11-ketotigogenin beta -O-cellobioside heptaalkanoate, and diosgenin beta -O-cellobioside heptaalkanoate are also disclosed. The process provides both high beta -anomeric selectivity and high yields.
More Like This:
| JP2023057980 | PHARMACEUTICAL FOR AIDS |
| WO/2021/110173 | LIPOSOME FORMULATION OF FLUTICASONE PROPIONATE |
| JP6920002 | Ophthalmic injection device |
Inventors:
Bush, Frank Earl
Goggin, Katharine Dee
Lambert, John F
Shine Russell Jay
Walinski, Stanley W
Goggin, Katharine Dee
Lambert, John F
Shine Russell Jay
Walinski, Stanley W
Application Number:
JP50232493A
Publication Date:
June 01, 1995
Filing Date:
April 02, 1993
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/56; C07J17/00; C07J71/00; (IPC1-7): C07J17/00; C07J71/00
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)