Title:
【発明の名称】3,4-ジヒドロ-2H-1-ベンゾピラン類のヒドラジド誘導体類
Document Type and Number:
Japanese Patent JPH07505625
Kind Code:
A
Abstract:
This invention relates to novel hydrazide acyl hydrazinium derivatives of certain 3,4-dihydro-2H-1-benzopyrans of formula (1), the stereoisomers and mixtures thereof, their inner salts, and the pharmaceutically acceptable salts thereof wherein R is H or C1-6 alkyl, R1 is C1-6 alkyl, R2 is H or -C(O)R, R3 and R4 are independently C1-6 alkyl; R5 is C1-6 alkyl, or (a) with R8 being H or halogeno, n is zero, 1, 2, or 3 and X is a halide, -S(O)3R6, or nothing when the inner salt is formed, R6 is H, C1-6 alkyl, phenyl or 4-methylphenyl, to the intermediates, processes and techniques for their preparation, to their ability to manifest the property of being free radical scavengers, and to their end-use application in the treatment of disease conditions capable of being ameliorated by free radical scavengers.
Inventors:
Grisal, Jay Martin
Schnorzer clawick martina
Franken, Volkenius
Schnorzer clawick martina
Franken, Volkenius
Application Number:
JP51746693A
Publication Date:
June 22, 1995
Filing Date:
March 12, 1993
Export Citation:
Assignee:
Merrell Dow Pharmaceuticals Inc.
International Classes:
A61K31/35; A61K31/352; A61K31/353; A61P1/04; A61P1/12; A61P3/02; A61P9/10; A61P29/00; C07D311/58; C07D311/66; C07D311/72; (IPC1-7): C07D311/58; A61K31/35; C07D311/66
Attorney, Agent or Firm:
Katsuro Sasai