Document Type and Number:
Japanese Patent JPH07506342
Kind Code:
A
Abstract:
In accordance with the present invention, there is provided a novel synthetic polypeptide derived from the first type III repeat of fibronectin. The synthetic polypeptide of the invention encompasses a fibronectin-fibronectin binding site, and is capable of inhibiting fibronectin matrix assembly. In contrast to previously identified fibronectin fragments that block fibronectin matrix assembly by blocking an initial event in matrix assembly (i.e., fibronectin binding to cells), the invention polypeptide appears to inhibit an intermediate step in matrix assembly, i.e., fibronectin self-association prior to the disulfide cross-linking that stabilizes the fibronectin matrix.
Application Number:
JP51349093A
Publication Date:
July 13, 1995
Filing Date:
February 01, 1993
Export Citation:
International Classes:
A61K38/00; A61P35/00; A61P43/00; C07K14/78; C12N15/12; C12P21/02; C12N15/09; C12R1/01; (IPC1-7): C07K14/78; A61K38/00