Title:
【発明の名称】TCF変異体
Document Type and Number:
Japanese Patent JPH07507328
Kind Code:
A
Abstract:
PCT No. PCT/JP93/01905 Sec. 371 Date Sep. 29, 1994 Sec. 102(e) Date Sep. 29, 1994 PCT Filed Dec. 27, 1993 PCT Pub. No. WO94/14845 PCT Pub. Date Jul. 7, 1994Modified TCF in which one or more amino-acid residues of the wild type TCF responsible for glycosylation are substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCFs have a longer biological half-lives without loss of their biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.
Inventors:
Kyouji Yamaguchi
Nobuyuki Shima
Akihiko Murakami
Masaaki Goto
Ei Tsuda
Hiroaki Masunaga
Reiko Takahira
Fumiko Ogaki
Ueda Shoji
Koji Higashi
Nobuyuki Shima
Akihiko Murakami
Masaaki Goto
Ei Tsuda
Hiroaki Masunaga
Reiko Takahira
Fumiko Ogaki
Ueda Shoji
Koji Higashi
Application Number:
JP51501694A
Publication Date:
August 10, 1995
Filing Date:
December 27, 1993
Export Citation:
Assignee:
Snow Brand Milk Products Co., Ltd.
International Classes:
C12N15/09; A61K38/00; A61P35/00; C07K14/475; C07K14/52; C12N1/21; C12N15/12; C12P21/02; C12R1/91; (IPC1-7): C07K14/52; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Kiyoya Fujino