Title:
【発明の名称】細胞接着のオリゴヌクレオチド調節
Document Type and Number:
Japanese Patent JPH08500736
Kind Code:
A
Abstract:
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
Inventors:
Bennett, Sea Frank
Mirabell, Christopher Kay
Mirabell, Christopher Kay
Application Number:
JP50733993A
Publication Date:
January 30, 1996
Filing Date:
August 27, 1993
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A61K31/00; A61K31/70; A61K31/7088; C12N15/09; A61P17/00; A61P17/06; A61P25/04; A61P29/00; A61P35/00; A61P35/04; C07H21/02; C07H21/04; C07K14/705; C12N15/113; C12Q1/68; A61K38/00; A61K48/00; (IPC1-7): C12N15/09; A61K31/70; C07H21/04
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)