Title:
【発明の名称】保存G▲下4▼コア配列を有するオリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH08500738
Kind Code:
A
Abstract:
Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.
Inventors:
Honey Kuck, Ronnie Sea
Anderson, Kevin Pea
Bennett, Sea Frank
Chang, Min-E
Brown-Driver, Vicky El
Ecker, David Jay
Vickers, Timothy A
Wyatt, Jacqueline Earl
Embash, Jean Lewis
Anderson, Kevin Pea
Bennett, Sea Frank
Chang, Min-E
Brown-Driver, Vicky El
Ecker, David Jay
Vickers, Timothy A
Wyatt, Jacqueline Earl
Embash, Jean Lewis
Application Number:
JP50929993A
Publication Date:
January 30, 1996
Filing Date:
September 29, 1993
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A01N43/04; A01N63/00; A61K31/70; A61P31/12; A61P31/16; C12N15/09; A61P35/00; C07H21/00; C07H21/04; C12N15/113; C12N15/115; C12N15/117; C12P19/34; C12Q1/68; C12Q1/70; A61K38/00; (IPC1-7): C12N15/09; A01N63/00; A61K31/70; C07H21/04
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)