Title:
【発明の名称】オンラインプロセスの流れおよび反応のモニタ
Document Type and Number:
Japanese Patent JPH08501489
Kind Code:
A
Abstract:
The present invention makes use of a single detector to monitor several process functions, e.g. reaction efficiency, reagent flow rates, the presence of empty reagent reservoirs, the absence of a chemical reactor column in the system, blockage of flow system, etc., at a single location in the flow system. In accordance with the detection scheme of the present invention, only one detector is required to accomplish the same, if not more, functions as many detectors in the prior art instruments. In the described embodiment, an optical detector is positioned downstream of a chemical reaction chamber. This detector monitors the effluent from the reaction chamber to monitor the reaction efficiency. It also monitors the system functions upstream of the reaction chamber. System flow rate is monitored by detecting the presence of a gas bubble which has been introduced into the system at a known instance. Depletion of reagents in the reservoirs can be detected by monitoring the absence of the reagents at the detector at times when the reagents are expected. The flow system may be periodically diagnosed to check for flow blockage or missing flow component, by monitoring the flow past the detector which corresponds to a predetermined succession of reagents introduced into the system. Any deviation from a predictable succession of changes in the flow monitored by the detector indicates possible blockage of the flow delivery system or missing flow components.
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Inventors:
Keenan, Charles A
Coassin, Peter Jay
Hell Frey, David Bee
Weiner, Roger
Dee, Jun-Gee
Coassin, Peter Jay
Hell Frey, David Bee
Weiner, Roger
Dee, Jun-Gee
Application Number:
JP50339494A
Publication Date:
February 20, 1996
Filing Date:
June 29, 1993
Export Citation:
Assignee:
Beckman Instruments Incorporated
International Classes:
C12M1/00; B01J19/00; C07H21/00; C07K1/04; G01F1/7086; C40B40/06; C40B60/14; (IPC1-7): B01J19/00; C12M1/00; C07H21/00
Attorney, Agent or Firm:
Matsunaga Nobuyuki