【発明の名称】製剤化合物

Title:

【発明の名称】製剤化合物

Document Type and Number:

Japanese Patent JPH08504804

Kind Code:

A

Abstract:

PCT No. PCT/GB93/02632 Sec. 371 Date Aug. 29, 1995 Sec. 102(e) Date Aug. 29, 1995 PCT Filed Dec. 22, 1993 PCT Pub. No. WO94/14814 PCT Pub. Date Jul. 7, 1994Sesquiterpenes obtainable from the fungal strain Acremonium strictum XO6/15/458, and phannaceutically and veterinarily acceptable salts thereof, are inhibitors of the binding of benzodiazepine to the GABA-benzodiazepine-Cl ionophore receptor complex. These compounds are prepared by (i) fermenting, in a source of carbon, nitrogen and inorganic salts, fungal strain XO6/15/458 (IMI 354451) or a mutant thereof which produces the sesquiterpenes, (ii) isolating the sesquiterpenes from the fermentation medium; and (iii) if desired, converting the sesquiterpene into a pharmaceutically or veterinarily acceptable salt.

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Inventors:

Reno Di Vincent
Obernai Gerrard Bernard
Cup Brent Raymond

Application Number:

JP51495694A

Publication Date:

May 28, 1996

Filing Date:

December 22, 1993

Export Citation:

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Assignee:

Zenova Limited

International Classes:

A61K31/35; A61P21/02; A61P25/08; A61P25/20; A61P43/00; C07D493/06; C07D493/16; C12P17/18; C12R1/645; (IPC1-7): C07D493/06; A61K31/35; C07D493/16; C12P17/18

Attorney, Agent or Firm:

Shunichiro Suzuki

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