Title:
【発明の名称】特にグラム陽性菌に誘導型糖ペプチド耐性を付与するタンパク質
Document Type and Number:
Japanese Patent JPH08505050
Kind Code:
A
Abstract:
The protein VanB of formula (I) (in Fig.) is new. (I) is implicated in Gram positive bacteria, in resistance to glycopeptides, partic. vancomycin (II), this resistance being inducible by (II) but not by teicoplanin. Also new are (1) functional fragments and modified forms of (I), (2) nucleic acid (A) encoding (I), (3) nucleotides which hybridise with (A) under stringent conditions and complementary fragments, (4) recombinant DNA contg. (A) or fragments, plus expression control elements, (5) recombinant cloning and expression vectors contg. (A) or its fragments, (6) recombinant host cells contg. such DNA or vectors, and (7) monoclonal or polyclonal antibodies (Ab) which recognise (I) specifically.
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Inventors:
Michelle Arthur
Deyutka-Malang, Sylvie
Evers, Stephan
Courbalan, Patrice
Deyutka-Malang, Sylvie
Evers, Stephan
Courbalan, Patrice
Application Number:
JP51486593A
Publication Date:
June 04, 1996
Filing Date:
December 17, 1993
Export Citation:
Assignee:
Unstated Paste Pasture
International Classes:
G01N33/50; A61K38/00; A61P31/04; C07H21/04; C07K14/195; C07K14/315; C07K16/12; C12N1/21; C12N9/00; C12N15/09; C12N15/31; C12P21/08; C12Q1/18; C12Q1/68; G01N33/15; G01N33/569; C12R1/185; (IPC1-7): C12N15/09; C07H21/04; C07K14/195; C07K16/12; C12N1/21; C12P21/08; C12Q1/68; G01N33/569
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)