Title:
【発明の名称】結晶性ペニシリン誘導体並びにその製造及び使用
Document Type and Number:
Japanese Patent JPH08505645
Kind Code:
A
Abstract:
PCT No. PCT/JP94/01855 Sec. 371 Date Mar. 21, 1995 Sec. 102(e) Date Mar. 21, 1995 PCT Filed Nov. 2, 1994 PCT Pub. No. WO95/12601 PCT Pub. Date May 11, 1995Crystalline sodium 2 alpha -methyl-2 beta -(1,2,3-triazol-1-yl) -methylpenam-3 alpha -carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated aqueous solution of sodium 2 alpha -methyl-2 beta -(1,2,3-triazol-1-yl)-methylpenam-3 alpha -carboxylate-1,1-dioxide (tazobactam sodium) a solvent selected from acetone and ethanol in an amount corresponding to a solvent to water ratio of between about 95:5 and 99:1 v/v and crystallizing the desired product from the solvent mixture. The crystalline tazobactam sodium monohydrate exhibits a high beta -lactamase inhibitory activity in combination with beta -lactam antibiotics.
Inventors:
Trickes,georg
Application Number:
JP51312495A
Publication Date:
June 18, 1996
Filing Date:
November 02, 1994
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
A61K31/43; A61K31/431; A61P31/04; C07D499/00; C07D499/86; C07D499/87; C07D499/897; (IPC1-7): C07D499/86; A61K31/43; C07D499/87; C07D499/897
Attorney, Agent or Firm:
Tadashi Hagino (3 outside)
Previous Patent: １，１−ビス−（４−ヒドロキシフェニル）−３，３，５−トリメチルシ...
Next Patent: スクアレンシンテターゼ及びプロテインファルネシルトランスフェラーゼ...
Next Patent: スクアレンシンテターゼ及びプロテインファルネシルトランスフェラーゼ...