Title:
【発明の名称】新規な双性イオン材料
Document Type and Number:
Japanese Patent JPH08506030
Kind Code:
A
Abstract:
PCT No. PCT/GB94/00178 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Jan. 28, 1994 PCT Pub. No. WO94/16749 PCT Pub. Date Aug. 4, 1994The present invention provides materials which comprise a surface having pendant zwitterionic groups Z comprising, as anion, a phosphate, sulphonate, carboxylate or phosphate-ester group or a phosphate ester group in which one or more of the ester oxygen atoms is replaced by -S-, -NH- or by a valence bond and, as cation, an ammonium, phosphonium or sulphonium moiety, provided that where the anion is a phosphate-ester group or derivative thereof or sulphonate and the cation is a trialkyl quaternary ammonium group (the alkyl groups each containing from 1 to 4 carbon atoms) and the group linking the anion and cation moieties is an alkylene group, the alkylene group, contains at least 5, preferably at least 6, and more preferably at least 7, carbon atoms. The materials have improved biocompatibility for instance as evidenced by reduced protein deposition and reduced platelet activation.
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Inventors:
Russell, The Jeremy Colin
The Charles, Stephen Alexander
Freeman, Lichyard Neil Templar
The Charles, Stephen Alexander
Freeman, Lichyard Neil Templar
Application Number:
JP51684394A
Publication Date:
July 02, 1996
Filing Date:
January 28, 1994
Export Citation:
Assignee:
Biocompatibles Limited
International Classes:
A61L27/00; A61L27/34; A61L33/00; A61L33/06; C07F9/09; C07F9/10; C08F20/10; C08F20/18; C08F20/26; C08F20/34; C08F20/52; C08F20/56; C08F26/10; C08G18/08; C08G18/30; C08G63/692; (IPC1-7): A61L27/00; A61L33/00; C07F9/09; C07F9/10; C08F20/18; C08F20/26; C08F20/34; C08F20/56; C08F26/10; C08G18/30
Attorney, Agent or Firm:
Heiyoshi Odashima