Title:
【発明の名称】血管内皮細胞増殖因子阻害剤
Document Type and Number:
Japanese Patent JPH08508161
Kind Code:
A
Abstract:
The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane region of the receptor for VEGF, a very selective growth factor for endothelial cells. The soluble forms of the receptors will bind the growth factor with high affinity but do not result in signal transduction. These soluble forms of the receptor bind VEGF and inhibit its function.
Inventors:
Kendall, Litchiard El
Thomas, Kenneth A. Juniar
Thomas, Kenneth A. Juniar
Application Number:
JP52104194A
Publication Date:
September 03, 1996
Filing Date:
February 25, 1994
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K38/00; A61P9/00; A61P43/00; C07K14/00; C07K14/47; C07K14/715; C12N5/00; C12N15/09; C12N5/10; C12N15/00; C12P21/00; C12P21/02; C12R1/91; (IPC1-7): C12N15/09; A61K38/00; C07K14/47; C07K14/715; C12P21/02
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)