Title:
【発明の名称】5HT▲下2C▼アンタゴニストとしてのインドリン誘導体
Document Type and Number:
Japanese Patent JPH08512299
Kind Code:
A
Abstract:
Compounds of formula (I), processes for their preparation and their use in medicine are disclosed: inoline or isoquinoline residue, or a 5-membered or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; R1 is hydrogen, C1-6 alkyl, halogen, CF3, NR7R8 or OR9 where R7, R8 and R9 are independently hydrogen, C1-6 alkyl or arylC1-6alkyl; R2 is hydrogen or C1-6 alkyl; R3 is C1-6 alkyl; n is 0 to 3; m is 0 to 4; and R4 groups are independently C1-6 alkyl optionally substituted by one or more halogen atoms, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, C1-6 alkylthio, C3-6cycloalkylthio, C3-6 cycloalkylC1C6 alkylthio, halogen, nitro, CF3, OCF3, SCF3, SO2CF3, SO2F, formyl, C2-6 alkanoyl, cyano, optionally substituted phenyl or thienyl, NR7R8, CONR7R8, or OR9 where R7, R8 and R9 are as defined for R1, CO2R10 where R10 is hydrogen or C1-6 alkyl.
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Inventors:
Ham, peter
Jones, Graham Elgin
Forbes, Ian Thomson
Jones, Graham Elgin
Forbes, Ian Thomson
Application Number:
JP50381295A
Publication Date:
December 24, 1996
Filing Date:
June 30, 1994
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/42; A61K31/44; A61K31/4427; A61K31/475; A61P1/14; A61P25/00; A61P25/26; A61P25/28; A61P43/00; C07D401/12; C07D413/12; (IPC1-7): C07D401/12; C07D413/12; A61K31/475; A61K31/44; A61K31/42
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)