Title:
【発明の名称】1‐デアミノ‐8‐D‐アルギニン・バソプレッシンの製造法
Document Type and Number:
Japanese Patent JPH09502423
Kind Code:
A
Abstract:
A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R1)-Tyr-Phe-Gln-Asn-Cys(R2)-Pro-OH (SEQ ID NO: 1), where R1 and R2 are sulfhydryl-protecting groups, with the dipeptide (R3)-D-Arg(HCl)-Gly-NH2, where R3 is an acid-sensitive amino-protecting group, to form Mpa(R1)-Tyr-Phe-Gln-Asn-Cys(R2)-Pro-D-Arg(HCl)-Gly-NH2 (SEQ ID NO: 1), which is oxidized with iodine in a protic solvent. The reaction mixture containing the oxidized product can be purified by ion exchange chromatography on a cation exchange resin equilibrated with acid. Also disclosed is high-purity DDAVP obtained by this process and its use for treating diurea.
Inventors:
Larson, Bo Ake Christer
Meerbrandt, Thomas Biem
Merunstamu, Eva Maria Birgitta
Rossie Star, Jan Anders Ingemar
Skelebetsk, Jan Ake
Meerbrandt, Thomas Biem
Merunstamu, Eva Maria Birgitta
Rossie Star, Jan Anders Ingemar
Skelebetsk, Jan Ake
Application Number:
JP50342495A
Publication Date:
March 11, 1997
Filing Date:
June 22, 1994
Export Citation:
Assignee:
Felling BV
International Classes:
A61K38/095; A61P7/10; C07K1/107; A61K38/04; C07K7/16; A61K38/00; (IPC1-7): C07K7/16; A61K38/04; C07K1/107
Attorney, Agent or Firm:
Keinosuke Ozawa (1 person outside)