Title:
【発明の名称】炎症を治療するための1,2-ジアリールシクロペンテニル化合物
Document Type and Number:
Japanese Patent JPH09504288
Kind Code:
A
Abstract:
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: I wherein A is selected from each of R1 and R2 is independently selected from hydrido, methyl, ethyl, fluoro, hydroxymethyl, carbomethoxy, trifluoromethyl, carboxyl and fluoromethyl; wherein each of R3, R4, R6 through R9, R11 and R12 is independently selected from hydrido, methyl, fluoro and chloro; and wherein each of R5 and R10 is independently selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, methoxy, methylthio, cyano, trifluoromethyl, hydroxymethyl, methoxymethyl, methylsulfonyl and sulfamyl; provided that when A is R5 cannot be hydrido when R10 is selected from hydrido, cyano, halo, methyl, trifluoromethyl and methoxy; further provided that R10 cannot be hydrido when R5 is selected from cyano, halo, methyl, trifluoromethyl and methoxy; and further provided that R5 and R10 are not both methoxy; or a pharmaceutically suitable salt thereof.
Inventors:
Reitz, David Bee.
Li, Jinglin
Li, Jinglin
Application Number:
JP51259395A
Publication Date:
April 28, 1997
Filing Date:
July 21, 1994
Export Citation:
Assignee:
G.D.Searle & Company
International Classes:
A61K31/10; A61K31/18; A61K31/275; A61K31/357; A61K31/36; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61P1/00; A61P1/02; C07D317/56; A61P3/06; A61P9/00; A61P11/00; A61P17/00; A61P19/02; A61P27/02; A61P29/00; A61P43/00; C07C311/16; C07C311/29; C07C317/14; C07C317/22; C07C317/44; C07C323/65; C07D213/34; (IPC1-7): C07C317/14; A61K31/10; A61K31/18; A61K31/275; A61K31/36; A61K31/44; C07C311/16; C07C311/29; C07C317/22; C07C317/44; C07C323/65; C07D213/34; C07D317/56
Attorney, Agent or Firm:
Akira Asamura (3 outside)