Title:
【発明の名称】記憶増強剤として有用な3-アリール-4-アルキルおよび4,5-ジアルキル-4H-1,2,4-トリアゾール類
Document Type and Number:
Japanese Patent JPH09504290
Kind Code:
A
Abstract:
This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by administration of 3-aryl-4-alkyl and 4,5-dialkyl-4H-1,2,4-triazoles of formula (I) wherein R1 and R2 independently represent hydrogen, halogen, trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy, or together, R1 and R2 represent -CH=CH-CH=CH-, forming a 1- or 2-naphthylenyl ring system; R3 represents hydrogen or C1-4 lower alkyl; and R4 represents C1-4 lower alkyl, benzyl, or benzyl substituted by one or two groups selected from halogen, trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy.
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Inventors:
Dalton, Christopher, Earl.
Kane, John, M.
Miller, Jerry, A.
Kane, John, M.
Miller, Jerry, A.
Application Number:
JP51264595A
Publication Date:
April 28, 1997
Filing Date:
October 04, 1994
Export Citation:
Assignee:
Merrell Farmers-Tikals Incorporated
International Classes:
A61K31/41; A61P25/28; C07D249/08; (IPC1-7): C07D249/08; A61K31/41
Attorney, Agent or Firm:
Katsuro Sasai