Title:
【発明の名称】発現ターゲティングのための癌胎児性抗原の転写制御配列
Document Type and Number:
Japanese Patent JPH09504957
Kind Code:
A
Abstract:
Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target-tissue specific transcriptional regulatory sequence (TRS) linked and controlling the expression of a heterologous enzyme, for example Varicella Zoster Virus Thymidine Kinase (VZV TK) or non-mammaliam Cytosine Deaminase(CD). A molecular chimaera is packaged into a synthetic retroviral particle that is capable of infecting mammalian tissue. This, in turn, may be administered to a host, and the TRS will be selectively transcriptionally activated in the target tissue (for example cancerous cells). Administration of compounds that are selectively metabolised by the enzyme produce cytotoxic or cytostatic metabolites in situ thereby selectively killing or arresting the growth of the target cells.
Inventors:
Richard, Cynthia Ann
Huber, Brian
Huber, Brian
Application Number:
JP51431695A
Publication Date:
May 20, 1997
Filing Date:
November 18, 1994
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
C12N15/00; A61K31/505; A61K31/70; A61K35/76; A61K38/45; A61K38/46; A61K38/48; A61K38/50; A61K48/00; A61P35/00; C07H19/06; C07H19/16; C07H21/00; C07H21/04; C07K14/765; C12N5/00; C12N5/10; C12N7/04; C12N9/12; C12N15/85; C12N15/867; C12R1/91; (IPC1-7): C12N15/00; A61K31/70; A61K35/76; A61K48/00; C07H21/04; C12N5/10; C12N7/01
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)