Title:
【発明の名称】結節硬化症2遺伝子及びその利用
Document Type and Number:
Japanese Patent JPH09507752
Kind Code:
A
Abstract:
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterised by widespread development of growths in many tissues and organs. A gene (TSC2) is identified on chromosome 16 which is mutated in TSC and which may behave as a tumour suppressor. Screening of actual or suspected TSC patients for normal or mutated TSC2 can be used for diagnostic purposes. TSC2 protein (tuberin) may be used to treat or prevent unrestrained cell division and/or tumour development in patients with or without TSC.
Inventors:
Sampson, Julian
Nellist, Mark, David
Brooke-Carter, Philip
Marshwar, Magita
Harley, Dilce, Jorainche Johanna
Iansen, Lambertus Anthony Jacobs
Hesselink, Ayenne Rick Wilhelma
Van den Aweland, Anna, Maria, Wilhelmina
Harris, Peter Charles
Ward, christopher james
Blainck, Martin Hendrick
Roelph Sema, Jerun, Hendrick
Nellist, Mark, David
Brooke-Carter, Philip
Marshwar, Magita
Harley, Dilce, Jorainche Johanna
Iansen, Lambertus Anthony Jacobs
Hesselink, Ayenne Rick Wilhelma
Van den Aweland, Anna, Maria, Wilhelmina
Harris, Peter Charles
Ward, christopher james
Blainck, Martin Hendrick
Roelph Sema, Jerun, Hendrick
Application Number:
JP51785895A
Publication Date:
August 12, 1997
Filing Date:
December 23, 1994
Export Citation:
Assignee:
University of Wales College of Medicine
Erasmus University Rotterdam
Medical Research Council
Rayden University
Erasmus University Rotterdam
Medical Research Council
Rayden University
International Classes:
G01N33/566; A61K31/70; A61K38/00; A61K39/395; A61K48/00; A61P13/02; A61P13/12; A61P15/00; A61P35/00; C07H21/02; C07H21/04; C07K14/46; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; C12R1/19; (IPC1-7): C12N15/09; A61K31/70; A61K38/00; A61K48/00; C07H21/02; C07H21/04; C07K14/47; C07K16/18; C12Q1/68; G01N33/566
Attorney, Agent or Firm:
Takashi Ishida (3 others)