組織又は器官移植片にＴ細胞耐性を誘発するための方法

Japanese Patent JPH09512271

A

Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.

アップル，マイケル シー．
グレンテール，デール エル．
ドゥリー，フィオナ エイチ．
ノエル，ランドルフ ジェイ．
パーカー，デビッド シー．
フィリップス，ナンシー イー．
モーデス，ジョン ピー．
ロッシーニ，アルド エー．

JP52774595A

December 09, 1997

April 25, 1995

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トラスティーズ オブ ダートマス カレッジ
ユニバーシティ オブ マサチューセッツ メディカルセンター

C12N15/02; A61K31/00; A61K35/14; A61K35/38; A61K38/17; A61K39/00; A61K39/395; A61P3/00; A61P3/10; A61P37/00; A61P37/06; C07K14/705; C07K16/28; C12P21/08; A61K38/00; C12R1/91; (IPC1-7): A61K39/395; C12N15/02

石田 敬 （外３名）

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