Title:
【発明の名称】良性前立腺過形成の治療のためのα-1c特異的化合物の使用
Document Type and Number:
Japanese Patent JPH10502335
Kind Code:
A
Abstract:
The subject invention provides a method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human alpha 1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human alpha 1A adrenergic receptor, a human alpha 1B adrenergic receptor, a human histamine H1 receptor and alpha 2 adrenergic receptor. The subject invention also provides a method of inhibiting contraction of prostate tissue which comprises contacting the prostate tissue with an effective contraction-inhibiting amount of such compound.
Inventors:
Gruchovsky, Charles
Foley, Carlos Sea
Chiu, George
Blanche, Teresa A
Betzel, John Em
Heartig, Paul Earl
Foley, Carlos Sea
Chiu, George
Blanche, Teresa A
Betzel, John Em
Heartig, Paul Earl
Application Number:
JP52699695A
Publication Date:
March 03, 1998
Filing Date:
April 04, 1995
Export Citation:
Assignee:
Synaptic Pharmaceuticals Corporation
International Classes:
A61K31/00; A61K31/135; A61K31/137; A61K31/435; A61K31/44; A61K31/4409; A61K45/00; A61K31/4427; A61K31/445; A61K31/4515; A61K31/454; A61K31/4545; A61K31/505; A61K31/517; A61K31/55; A61P13/02; A61P15/00; A61P43/00; C07C211/30; C07C215/50; C07C215/52; C07C217/58; C07C217/60; C07D211/58; C07D401/12; C07D405/12; C07D495/06; (IPC1-7): A61K45/00; A61K31/135; A61K31/435; A61K31/44; A61K31/505; A61K31/55
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)