Title:
【発明の名称】抗ヘリコバクター性アゾロン類の尿素およびチオ尿素誘導体
Document Type and Number:
Japanese Patent JPH10502384
Kind Code:
A
Abstract:
The invention is concerned with the compounds having the formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is C1-4alkyl; C1-4alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C1-4alkyl; Z is C=O or CHOH; and is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7) Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
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Inventors:
Jerez, Jiang
Stoke Brex, Raymond Antoine
Willem, Marc
Van der Ahe, Marcel Joseph Joseph Maria
Stoke Brex, Raymond Antoine
Willem, Marc
Van der Ahe, Marcel Joseph Joseph Maria
Application Number:
JP50411095A
Publication Date:
March 03, 1998
Filing Date:
July 05, 1995
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/415; A61K31/495; A61K31/50; A61K31/505; A61P1/00; A61P1/04; A61P31/04; C07D233/70; C07D249/12; C07D401/04; C07D403/04; (IPC1-7): C07D249/12; A61K31/415; A61K31/495; A61K31/50; A61K31/505; C07D233/70; C07D401/04
Attorney, Agent or Firm:
Heiyoshi Odashima