Title:
【発明の名称】キメラ免疫無防備状態動物における長期間異種骨髄性およびリンパ性細胞生産
Document Type and Number:
Japanese Patent JPH10504454
Kind Code:
A
Abstract:
Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8-, CD8+CD4- as well as a high percentage of immature double positive CD4+CD8+ populations.
More Like This:
Inventors:
Chen, Benjamin Pee
Fraser, Christopher Sea
Fraser, Christopher Sea
Application Number:
JP50702295A
Publication Date:
May 06, 1998
Filing Date:
August 11, 1995
Export Citation:
Assignee:
Sand Limited
Systemics Inc.
Systemics Inc.
International Classes:
A01K67/027; G01N33/569; (IPC1-7): A01K67/027
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)