Title:
【発明の名称】感覚および運動ニューロンにより誘導される因子(SMDF)
Document Type and Number:
Japanese Patent JPH10509149
Kind Code:
A
Abstract:
Isolated SMDF, isolated DNA encoding SMDF, and recombinant or synthetic methods of preparing SMDF are disclosed. SMDF contains a beta -type EGF-like domain and a N-terminal sequence which is distinct from all neuregulins reported so far. SMDF, when expressed in recombinant cell culture, activates tyrosine phosphorylation of the HER2/neu receptor in human breast cancer cells and displays mitogenic activity on Schwann cells. Northern blot and in situ hybridization analysis show that SMDF differs from other neuregulins in that it is nervous tissue specific, and is very highly expressed, in comparison to other neuregulins, in the human and rat spinal cord motor neurons and sensory neurons.
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Inventors:
Ho, Way-Shen
Ocherov, Philis El
Ocherov, Philis El
Application Number:
JP51619396A
Publication Date:
September 08, 1998
Filing Date:
November 08, 1995
Export Citation:
Assignee:
Genentech Incorporated
International Classes:
G01N33/53; A61K38/00; A61P25/00; C07K14/47; C07K14/52; C07K16/24; C12N5/07; C12N5/0793; C12N5/09; C12N15/00; C12N15/02; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12R1/91; (IPC1-7): C07K14/52; A61K38/00; C07K16/24; C12N5/06; C12N15/02; C12N15/09; C12P21/02; C12P21/08; G01N33/53
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)