Title:
【発明の名称】多薬耐性活性を改良した新規なアミノ酸誘導体
Document Type and Number:
Japanese Patent JPH10509151
Kind Code:
A
Abstract:
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
Inventors:
Soll, Robert E.
Harding, Matthew W.
Harding, Matthew W.
Application Number:
JP51630696A
Publication Date:
September 08, 1998
Filing Date:
November 13, 1995
Export Citation:
Assignee:
Vertex Pharmaceuticals, Inc.
International Classes:
A61K31/16; A61K31/165; A61K31/395; A61K31/41; A61K31/42; A61K31/421; A61K31/4245; A61K31/44; A61K31/4406; A61K31/4409; A61K31/4418; A61P35/00; C07C231/02; C07C237/22; C07C309/51; C07C309/59; C07C317/28; C07C323/41; C07D213/38; C07D213/40; C07D333/06; C07D213/50; C07D213/56; C07D233/54; C07D233/90; C07D261/08; C07D263/32; C07D271/04; C07D277/20; C07D277/22; C07D277/38; C07D277/64; C07D333/36; C07D521/00; A61K31/00; C07C237/00; (IPC1-7): C07C237/22; A61K31/16; A61K31/165; A61K31/41; A61K31/42; A61K31/44; C07C231/02; C07C309/51; C07C309/59; C07C317/28; C07C323/41; C07D213/56; C07D261/08; C07D263/32; C07D271/04; C07D277/22; C07D277/38; C07D277/64; C07D333/06; C07D333/36
Attorney, Agent or Firm:
Shusaku Yamamoto