Title:
【発明の名称】レクザイム及び糖質リガンドの同定浄化及び使用
Document Type and Number:
Japanese Patent JPH10510424
Kind Code:
A
Abstract:
The present invention provides a substantially purified carbohydrate ligand that specifically binds to a leczyme. The invention also provides methods to identify a carbohydrate ligand that specifically binds to a leczyme or a leczyme that specifically binds to a carbohydrate ligand. The invention further provides methods to identify a peptide that binds to the carbohydrate ligand binding site of a leczyme. The present invention provides methods to isolate a carbohydrate ligand or a leczyme and to identify a carbohydrate ligand or a leczyme that modifies the function of a cell and to obtain such functionally modified cells. The invention further provides methods to modify a cell to express a carbohydrate ligand by introducing an expression vector encoding a leczyme into the cell. The invention also provides methods to modulate the immune response to an antigen by administering the antigen and a carbohydrate ligand. In addition, the invention further provides methods to treat a disease state involving a leczyme by administering a carbohydrate ligand that binds the leczyme or by administering a leczyme that has a similar binding specificity to the leczyme involved in the disease state. The invention further provides methods to diagnose a genetic basis for hemochromatosis by detecting a mutation in a class I MHC molecule that reduces it's ability to associate with beta2 microglobulin.
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Inventors:
Rosenberg Barry E.
Application Number:
JP51777796A
Publication Date:
October 13, 1998
Filing Date:
December 06, 1995
Export Citation:
Assignee:
Rosenberg Barry E.
International Classes:
G01N33/53; A61K31/70; A61K31/715; A61K35/76; A61K38/43; A61K38/45; A61K39/39; A61K45/00; A61K47/48; A61K48/00; A61P3/00; A61P29/00; A61P31/00; A61P37/04; C07H1/08; C07K14/47; C07K14/74; C12N5/08; C12N9/00; C12N15/09; C12Q1/68; G01N33/566; G01N33/573; A61K38/00; (IPC1-7): C12N15/09; A61K31/70; A61K31/715; A61K35/76; A61K38/43; A61K38/45; A61K39/39; A61K45/00; A61K47/48; A61K48/00; C07H1/08; C07K14/74; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Motohiko Fujimura (1 outside)