Title:
【発明の名称】スピロケタール誘導体、該誘導体を含有する組成物、及び該誘導体の治療薬としての使用
Document Type and Number:
Japanese Patent JPH10511381
Kind Code:
A
Abstract:
PCT No. PCT/GB95/02927 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 15, 1995 PCT Pub. No. WO96/20197 PCT Pub. Date Jul. 4, 1996The present invention relates to spiroketal derivatives of formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R9a, R9b, m and n are as defined in the specification, and to processes for their preparation, to intermediates used in their synthesis, to pharmaceutical compositions containing them, and to their use in therapy. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. (I)
Inventors:
Harrison, Tamothy
Owen, Simon Neil
Sireward, Irene Marie
Swayne, Christopher Jiyoung
Owen, Simon Neil
Sireward, Irene Marie
Swayne, Christopher Jiyoung
Application Number:
JP52027596A
Publication Date:
November 04, 1998
Filing Date:
December 15, 1995
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/535; A61P1/08; A61P25/04; A61P25/06; A61P29/00; C07D498/10; (IPC1-7): C07D498/10; A61K31/535
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)