Title:
【発明の名称】ヘルペスウィルス感染症の再発防止薬
Document Type and Number:
Japanese Patent JPH10511952
Kind Code:
A
Abstract:
N2-substituted alkylguanine and N2-substituted phenylguanine compounds which prevent recurrent herpes simplex infections are disclosed. By virtue of their ability to inhibit herpes virus thymidine kinase in vivo, such compounds will prevent, reduce the frequency of, or reduce the severity of recurring HSV infections in humans. The N2-alkylguanine compounds are of the formula: where R1 is a normal or branched chain CnH2n+1 (where n is 1-12); R2 is H, 2-deoxyribofuranosyl, (CH2)nOH (where n is 2-5), CH2CH(OH)CH2OH, (CH2)n-COOH (where n is 1-4), CH2CH(OH)CH2-O-COR4, (CH2)n-O-COR4 (where n is 2-5), or (CH2)nCO-OR4 (where n is 1-4); R4 is CH3, CH2CH3, CH2CH2NH2, CH2CH2N(C2H5)2 or CH2CH2CO2H; and R3 is OH, H, Cl or NH2, or a tautomer or a pharmaceutically acceptable salt thereof. The N2-substituted phenylguanine compounds are of similar structure, where R1 is a phenyl or a phenyl substituted at the 3 and 4 positions with an H, a hydrophobic or electron extracting group, or a CH2CH3.
Inventors:
Light George E
Application Number:
JP52111996A
Publication Date:
November 17, 1998
Filing Date:
December 28, 1995
Export Citation:
Assignee:
University of Massachusetts Medical Center
International Classes:
C07D473/16; A61K31/52; A61K31/522; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61K31/708; A61P31/12; A61P31/22; C07D473/00; C07D473/18; C07D473/32; C07D473/40; C07H19/16; C07H19/173; (IPC1-7): C07D473/32; A61K31/52; A61K31/70; C07D473/16; C07D473/18; C07D473/40; C07H19/173
Attorney, Agent or Firm:
Kenji Yoshida (2 outside)