Title:
【発明の名称】結晶性トリメトレキセート塩及びその製造法
Document Type and Number:
Japanese Patent JPH10512261
Kind Code:
A
Abstract:
The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.
Inventors:
Kennedy, Paul, Yi.
Graphe, ingomer
Morsdorf, Johann, Pee.
Ahrens, Kurt-Henning
Graphe, ingomer
Morsdorf, Johann, Pee.
Ahrens, Kurt-Henning
Application Number:
JP52171096A
Publication Date:
November 24, 1998
Filing Date:
January 11, 1996
Export Citation:
Assignee:
Kennedy, Paul, Yi.
Graphe, ingomer
Morsdorf, Johann, Pee.
Ahrens, Kurt-Henning
Graphe, ingomer
Morsdorf, Johann, Pee.
Ahrens, Kurt-Henning
International Classes:
A61K31/505; A61K31/517; C07D239/95; (IPC1-7): C07D239/95; A61K31/505
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)