Title:
【発明の名称】免疫治療剤として役立つポリペプチド及びポリペプチド調製の方法
Document Type and Number:
Japanese Patent JPH11501804
Kind Code:
A
Abstract:
Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.
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Inventors:
Whittle, Nigel Richard
Carmichael, Jeremy Paddon
Connor, Stephen Edward
Henry Stephen Glamour, Thompson
Wilson, Mark Jonathan
Carmichael, Jeremy Paddon
Connor, Stephen Edward
Henry Stephen Glamour, Thompson
Wilson, Mark Jonathan
Application Number:
JP52549696A
Publication Date:
February 16, 1999
Filing Date:
February 23, 1996
Export Citation:
Assignee:
Cantab Pharmaceuticals Research Limited
International Classes:
A61K39/12; A61P31/12; C07K14/025; C07K19/00; C12N15/00; C12N15/37; C12P21/02; C12N15/09; C12R1/92; (IPC1-7): C12N15/09; A61K39/12; C07K14/025; C07K19/00; C12P21/02
Domestic Patent References:
| JPH04227000A | 1992-08-17 | |||
| JPH04217998A | 1992-08-07 | |||
| JPH06508988A | 1994-10-13 | |||
| JPH06505626A | 1994-06-30 | |||
| JPH05506145A | 1993-09-16 | |||
| JPH04505452A | 1992-09-24 |
Foreign References:
| WO1994020137A1 | 1994-09-15 | |||
| WO1993002184A1 | 1993-02-04 | |||
| WO1992005248A1 | 1992-04-02 | |||
| WO1993020844A1 | 1993-10-28 |
Attorney, Agent or Firm:
Takashi Ishida (3 others)