Title:
【発明の名称】免疫疾患の治療および診断のための組成物および方法
Document Type and Number:
Japanese Patent JPH11501807
Kind Code:
A
Abstract:
The present invention relates to methods and compositions for the treatment of immune disorders, especially T helper (TH) cell and TH cell-like related disorders. First, genes are identified and described which are differentially expressed within and among TH cells and TH cell subpopulations. Second, genes are identified and described which are differentially expressed within TH cell subpopulations in TH cell subpopulation-related disorders. The modulation of the expression of the identified genes and/or activity of the identified gene products can be utilized therapeutically to ameliorate immune disorder symptoms and to modulate TH cell responsiveness, for example, responsiveness to antigen. Further, the identified genes and/or gene products can be used to diagnose individuals exhibiting or predisposed to such immune disorders. Still further, the identified genes and/or gene products can be used to detect TH cell responsiveness, for example, responsivenem to antigen.
Inventors:
Levinson, Douglas, A.
Application Number:
JP52694996A
Publication Date:
February 16, 1999
Filing Date:
March 01, 1996
Export Citation:
Assignee:
Merenium Pharmaceuticals, Inc.
International Classes:
A01K67/027; A61K38/00; A61K39/395; A61K48/00; A61P3/08; A61P3/10; A61P11/06; A61P29/00; A61P31/04; A61P37/00; A61P37/02; A61P37/08; B60G13/00; C07K14/52; C07K14/705; C07K14/725; C07K16/24; C07K19/00; C12N1/21; C12N5/10; C12N7/01; C12N9/64; C12N15/09; C12N15/85; C12Q1/68; G01N33/15; G01N33/564; (IPC1-7): C12N15/09; A01K67/027; A61K38/00; A61K39/395; A61K48/00; C07K14/52; C07K16/24; C07K19/00; C12N5/10; G01N33/15; G01N33/564
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)