Title:
【発明の名称】単離された、プロセシングされていないポリペプチドを使用するプラス鎖RNAウイルスの診断およびプラス鎖RNAウイルスに対するワクチン接種
Document Type and Number:
Japanese Patent JPH11506328
Kind Code:
A
Abstract:
The unprocessed polyprotein initially translated from the genome of a positive-stranded RNA virus contains epitopic configurations that are not retained in the processed proteins. The structural protein region, in particular, loses an epitopic configuration upon processing at the cleavage site between the genomic region encoding the core protein and the genomic region encoding the protein adjacent the core protein, such as the envelope protein in HCV. Compositions, methods and assays relating to the diagnosis and detection of the presence of the positive-stranded RNA virus, or antibodies to the positive-stranded RNA virus, in a sample. Compositions and methods for the induction of immune responses in, and vaccination of, an animal. Combination of the unprocessed core region with a non-structural protein (such as an NS5 or an unprocessed NS3-NS4 fusion from HCV).
Inventors:
Riao, Jau-chin
Wang, Chen-Nang
Wang, Chen-Nang
Application Number:
JP53667796A
Publication Date:
June 08, 1999
Filing Date:
May 31, 1996
Export Citation:
Assignee:
Bio Nova Corporation
International Classes:
G01N33/569; A61K39/12; A61K39/125; A61K39/21; A61K39/215; A61K39/29; A61P1/16; A61P31/12; A61P35/02; C07K14/155; C07K14/18; C07K16/10; C12N7/00; C12N15/00; C12N15/09; C12P21/02; C12P21/08; C12Q1/70; G01N33/576; A61K39/00; C12R1/19; C12R1/92; (IPC1-7): C12N15/09; A61K39/12; A61K39/125; A61K39/21; A61K39/215; A61K39/29; C07K14/155; C07K14/18; C07K16/10; C12N7/00; C12P21/02; G01N33/569; G01N33/576
Attorney, Agent or Firm:
Shusaku Yamamoto